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Hematological and Liver Function of Plasmodium Berghei Positive Wister Treated With Herbs and Acts

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Hematological and Liver Function of Plasmodium Berghei Positive Wister Treated With Herbs and Acts


Nwaisaac Ikechukwu Samuel | Igbokwe Vincent Ugochukwu | Okonkwo Chukwudi Onyeka | Okpa Precious Nwaka | Nnyaha Anthonia Ekenedilichukwu | Ajeka Prisca



Nwaisaac Ikechukwu Samuel | Igbokwe Vincent Ugochukwu | Okonkwo Chukwudi Onyeka | Okpa Precious Nwaka | Nnyaha Anthonia Ekenedilichukwu | Ajeka Prisca "Hematological and Liver Function of Plasmodium Berghei Positive Wister Treated With Herbs and Acts" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5, August 2021, pp.1979-1985, URL: https://www.ijtsrd.com/papers/ijtsrd46277.pdf

Eradication of malaria in Africa continues to be one of the greatest challenges in the health sector. All the drugs developed thus far have their limitations and are generally expensive. In Africa and Nigeria the use of herbs in treating sicknesses dated as far back as the existence of man and is still in use today by many Nigerians in rural areas. Here we evaluated the therapeutic efficacy of ethanolic extract for three of these herbs (lemon grass, lime and turmeric) used singly and in combination on Plasmodium berghei infected rats. Results reveals that there was an 81.54% reduction in parasite level in groups treated with herbs and an 88.9% reduction in those treated with ACTs. The time frame of this study wasn’t enough to determine if there will be a resurgence in the parasitemia level. Results from the liver function test also reveals that the herbs also reduced the levels of liver enzymes in the serum but the results from the liver histology from the onset shows little or no damage to the liver; This helps us to understand that the plasmodium parasites does not cause much damage to the liver cells or requires more time to do so. Hence the study concludes that potent herbs like turmeric, lemon grass and lime although not as effective as ACTs but if harnessed properly can be substituted for ACTs in treating malaria in low income rural areas of Nigeria.

Plasmodium Berghei, liver function, haematology


IJTSRD46277
Volume-5 | Issue-5, August 2021
1979-1985
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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